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Factor VII (F7) Human Gene Knockout Kit (CRISPR)

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SKU
KN213143RB
F7 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

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Other products for "Factor VII or NM_000131"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol Factor VII
Locus ID 2155
Components

KN213143G1, Factor VII gRNA vector 1 in pCas-Guide CRISPR vector

KN213143G2, Factor VII gRNA vector 2 in pCas-Guide CRISPR vector

KN213143RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000131, NM_001267554, NM_019616, NR_051961
UniProt ID P08709
Synonyms SPCA
Summary This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. provided by RefSeq, Aug 2015
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Other Versions
SKU Description Size Price
GA101501 F7 CRISPRa kit - CRISPR gene activation of human coagulation factor VII 1 kit
$1,657.00
KN213143 F7 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213143BN F7 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213143LP F7 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN413143 F7 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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