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TGF beta 2 (TGFB2) Human Gene Knockout Kit (CRISPR)

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SKU
KN212624RB
TGFB2 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

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Other products for "TGF beta 2 or M19154"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol TGF beta 2
Locus ID 7042
Components

KN212624G1, TGF beta 2 gRNA vector 1 in pCas-Guide CRISPR vector

KN212624G2, TGF beta 2 gRNA vector 2 in pCas-Guide CRISPR vector

KN212624RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001135599, NM_003238, NR_138148, NR_138149
UniProt ID P61812
Synonyms G-TSF; LDS4; TGF-beta2
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. provided by RefSeq, Aug 2016
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Documents
Resources
Other Versions
SKU Description Size Price
GA104849 TGFB2 CRISPRa kit - CRISPR gene activation of human transforming growth factor beta 2 1 kit
$1,657.00
KN212624 TGFB2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN212624BN TGFB2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN212624LP TGFB2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN412624 TGFB2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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