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KSR2 Human Gene Knockout Kit (CRISPR)

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SKU
KN211665LP
KSR2 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (4)

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RC211665 KSR2 (Myc-DDK-tagged)-Human kinase suppressor of ras 2 (KSR2)
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Other products for "KSR2 or XM_011538230"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol KSR2
Locus ID 283455
Components

KN211665G1, KSR2 gRNA vector 1 in pCas-Guide CRISPR vector

KN211665G2, KSR2 gRNA vector 2 in pCas-Guide CRISPR vector

KN211665LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_173598
UniProt ID Q6VAB6
Synonyms FLJ25965
Summary Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
GA117027 KSR2 CRISPRa kit - CRISPR gene activation of human kinase suppressor of ras 2 1 kit
$1,657.00
KN211665 KSR2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN211665BN KSR2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN211665RB KSR2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN411665 KSR2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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