HIP1 Human Gene Knockout Kit (CRISPR)

SKU KN211418BN

HIP1 - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Vector: mBFP-Neo
• Target Symbol: HIP1
• Locus ID: 3092
• Components:

  KN211418G1, HIP1 gRNA vector 1 in pCas-Guide CRISPR vector

  KN211418G2, HIP1 gRNA vector 2 in pCas-Guide CRISPR vector

  KN211418BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001243198, NM_005338
• UniProt ID: O00291
• Synonyms: HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma
• Summary: The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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