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Amyloid Precursor Protein (APP) Human Gene Knockout Kit (CRISPR)

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SKU
KN209575BN
APP - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Amyloid Precursor Protein or NM_000484"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol Amyloid Precursor Protein
Locus ID 351
Components

KN209575G1, Amyloid Precursor Protein gRNA vector 1 in pCas-Guide CRISPR vector

KN209575G2, Amyloid Precursor Protein gRNA vector 2 in pCas-Guide CRISPR vector

KN209575BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000484, NM_001136016, NM_001136129, NM_001136130, NM_001136131, NM_001204301, NM_001204302, NM_001204303, NM_201413, NM_201414
UniProt ID P05067
Synonyms AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
Summary This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. provided by RefSeq, Aug 2014
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Documents
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Other Versions
SKU Description Size Price
GA100249 APP CRISPRa kit - CRISPR gene activation of human amyloid beta precursor protein 1 kit
$1,657.00
KN209575 APP - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209575LP APP - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209575RB APP - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN409575 APP - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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