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Human Amyloid Precursor Protein (APP) activation kit by CRISPRa

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SKU
GA100249
APP CRISPRa kit - CRISPR gene activation of human amyloid beta precursor protein
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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Other products for "APP"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol APP
Locus ID 351
Components

GA100249G1, Amyloid Precursor Protein gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA100249G2, Amyloid Precursor Protein gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA100249G3, Amyloid Precursor Protein gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000484, NM_001136016, NM_001136129, NM_001136130, NM_001136131, NM_001204301, NM_001204302, NM_001204303, NM_201413, NM_201414
UniProt ID P05067
Synonyms AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
Summary This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. provided by RefSeq, Aug 2014
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Documents
Resources
Other Versions
SKU Description Size Price
KN209575 APP - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209575BN APP - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209575LP APP - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209575RB APP - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN409575 APP - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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