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Endostatin (COL18A1) Human Gene Knockout Kit (CRISPR)

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SKU
KN209465LP
COL18A1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Endostatin or NM_030582"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Endostatin
Locus ID 80781
Components

KN209465G1, Endostatin gRNA vector 1 in pCas-Guide CRISPR vector

KN209465G2, Endostatin gRNA vector 2 in pCas-Guide CRISPR vector

KN209465LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_030582, NM_130444, NM_130445
UniProt ID P39060
Synonyms KNO; KNO1; KS
Summary This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. provided by RefSeq, Dec 2014
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Documents
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Other Versions
SKU Description Size Price
GA112983 COL18A1 CRISPRa kit - CRISPR gene activation of human collagen type XVIII alpha 1 chain 1 kit
$1,657.00
KN209465 COL18A1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209465BN COL18A1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209465RB COL18A1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN409465 COL18A1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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