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Human Endostatin (COL18A1) activation kit by CRISPRa

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SKU
GA112983
COL18A1 CRISPRa kit - CRISPR gene activation of human collagen type XVIII alpha 1 chain
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA351157 Rabbit Polyclonal Anti-COL18A1 Antibody
100 ul
$205.00
RC209465 COL18A1 (Myc-DDK-tagged)-Human collagen, type XVIII, alpha 1 (COL18A1), transcript variant 2
10 ug
$1,714.00

Other products for "COL18A1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol COL18A1
Locus ID 80781
Components

GA112983G1, Endostatin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA112983G2, Endostatin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA112983G3, Endostatin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_030582, NM_130444, NM_130445
UniProt ID P39060
Synonyms KNO; KNO1; KS
Summary This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. provided by RefSeq, Dec 2014
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Documents
Resources
Other Versions
SKU Description Size Price
KN209465 COL18A1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209465BN COL18A1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209465LP COL18A1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209465RB COL18A1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN409465 COL18A1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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