SOCS3 Human Gene Knockout Kit (CRISPR)
CAT#: KN209305LP
SOCS3 - human gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro RFP-BSD mBFP-Neo
HDR-mediated knockout kit validation
USD 1,657.00
4 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control |
Donor DNA | Luciferase-Puro |
Symbol | SOCS3 |
Locus ID | 9021 |
Components |
KN209305G1, SOCS3 gRNA vector 1 in pCas-Guide CRISPR vector KN209305G2, SOCS3 gRNA vector 2 in pCas-Guide CRISPR vector KN209305LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_003955 |
UniProt ID | O14543 |
Synonyms | ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3 |
Summary | This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008] |
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Other Versions
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KN209305 | SOCS3 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN209305BN | SOCS3 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN209305RB | SOCS3 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN409305 | SOCS3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,657.00 |
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GA105994 | SOCS3 CRISPRa kit - CRISPR gene activation of human suppressor of cytokine signaling 3 |
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