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Von Hippel Lindau (VHL) Human Gene Knockout Kit (CRISPR)

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SKU
KN208875LP
VHL - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Von Hippel Lindau or NM_000551"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Von Hippel Lindau
Locus ID 7428
Components

KN208875G1, Von Hippel Lindau gRNA vector 1 in pCas-Guide CRISPR vector

KN208875G2, Von Hippel Lindau gRNA vector 2 in pCas-Guide CRISPR vector

KN208875LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000551, NM_198156, NM_001354723
UniProt ID P40337
Synonyms HRCA1; pVHL; RCA1; VHL1
Summary Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
GA105119 VHL CRISPRa kit - CRISPR gene activation of human von Hippel-Lindau tumor suppressor 1 kit
$1,657.00
KN208875 VHL - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN208875BN VHL - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN208875RB VHL - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN408875 VHL - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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