ST8SIA4 Human Gene Knockout Kit (CRISPR)

SKU KN208764RB

ST8SIA4 - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
• Vector: RFP-BSD
• Target Symbol: ST8SIA4
• Locus ID: 7903
• Components:

  KN208764G1, ST8SIA4 gRNA vector 1 in pCas-Guide CRISPR vector

  KN208764G2, ST8SIA4 gRNA vector 2 in pCas-Guide CRISPR vector

  KN208764RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_005668, NM_175052
• UniProt ID: Q92187
• Synonyms: PST; PST1; SIAT8D; ST8SIA-IV
• Summary: The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
• Shipping: Ambient