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TMPRSS2 Human Gene Knockout Kit (CRISPR)

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SKU
KN208677LP
TMPRSS2 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "TMPRSS2 or NM_001135099"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol TMPRSS2
Locus ID 7113
Components

KN208677G1, TMPRSS2 gRNA vector 1 in pCas-Guide CRISPR vector

KN208677G2, TMPRSS2 gRNA vector 2 in pCas-Guide CRISPR vector

KN208677LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001135099, NM_005656
UniProt ID O15393
Synonyms PP9284; PRSS10
Summary This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Apr 2020
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Documents
Resources
Other Versions
SKU Description Size Price
GA104914 TMPRSS2 CRISPRa kit - CRISPR gene activation of human transmembrane serine protease 2 1 kit
$1,657.00
KN208677 TMPRSS2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN208677BN TMPRSS2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN208677RB TMPRSS2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN408677 TMPRSS2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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