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DFFB Human Gene Knockout Kit (CRISPR)

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SKU
KN208266BN
DFFB - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "DFFB or NM_001004285"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol DFFB
Locus ID 1677
Components

KN208266G1, DFFB gRNA vector 1 in pCas-Guide CRISPR vector

KN208266G2, DFFB gRNA vector 2 in pCas-Guide CRISPR vector

KN208266BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001004285, NM_001004286, NM_001282669, NM_001320132, NM_001320136, NM_004402, NR_104222, NR_135150, NR_135151, NR_135152
UniProt ID O76075
Synonyms CAD; CPAN; DFF-40; DFF2; DFF40
Summary Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. provided by RefSeq, Sep 2013
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Documents
Resources
Other Versions
SKU Description Size Price
GA101187 DFFB CRISPRa kit - CRISPR gene activation of human DNA fragmentation factor subunit beta 1 kit
$1,657.00
KN208266 DFFB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN208266LP DFFB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN208266RB DFFB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN408266 DFFB - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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