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Human DFFB activation kit by CRISPRa

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SKU
GA101187
DFFB CRISPRa kit - CRISPR gene activation of human DNA fragmentation factor subunit beta
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA322750 Anti-DFFB Rabbit Polyclonal Antibody
100 ul
$305.00
RC208266 DFFB (Myc-DDK-tagged)-Human DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) (DFFB)
10 ug
$289.00 $457.00

Other products for "DFFB"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol DFFB
Locus ID 1677
Components

GA101187G1, DFFB gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101187G2, DFFB gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101187G3, DFFB gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001004285, NM_001004286, NM_001282669, NM_001320132, NM_001320136, NM_004402, NR_104222, NR_135150, NR_135151, NR_135152
UniProt ID O76075
Synonyms CAD; CPAN; DFF-40; DFF2; DFF40
Summary Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. provided by RefSeq, Sep 2013
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Documents
Resources
Other Versions
SKU Description Size Price
KN208266 DFFB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN208266BN DFFB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN208266LP DFFB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN208266RB DFFB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN408266 DFFB - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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