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NKG2D (KLRK1) Human Gene Knockout Kit (CRISPR)

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SKU
KN208050LP
KLRK1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "NKG2D or NM_007360"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol NKG2D
Locus ID 22914
Components

KN208050G1, NKG2D gRNA vector 1 in pCas-Guide CRISPR vector

KN208050G2, NKG2D gRNA vector 2 in pCas-Guide CRISPR vector

KN208050LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_007360
UniProt ID P26718
Synonyms CD314; D12S2489E; KLR; NKG2-D; NKG2D
Summary Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. provided by RefSeq, Dec 2010
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Documents
Resources
Other Versions
SKU Description Size Price
GA107907 KLRK1 CRISPRa kit - CRISPR gene activation of human killer cell lectin like receptor K1 1 kit
$1,657.00
KN208050 KLRK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN208050BN KLRK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN208050RB KLRK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN408050 KLRK1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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