NKG2D (KLRK1) Human Gene Knockout Kit (CRISPR)
$1,657.00
4 Weeks*
Product Data | |
Format | 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control |
---|---|
Vector | mBFP-Neo |
Target Symbol | NKG2D |
Locus ID | 22914 |
Components |
KN208050G1, NKG2D gRNA vector 1 in pCas-Guide CRISPR vector KN208050G2, NKG2D gRNA vector 2 in pCas-Guide CRISPR vector KN208050BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector |
OTI Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_007360 |
UniProt ID | P26718 |
Synonyms | CD314; D12S2489E; KLR; NKG2-D; NKG2D |
Summary | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010] |
Shipping | Ambient |
More linear donor DNA can be ordered separately
Cat# | KN208050BND |
Description | 10 ug linear donor DNA for KN208050BN kit |
Price | $515/€515 |
If you want to order 50ug, please order quantity of 5 for KN208050BND
Other selection marker is available for donor DNA.
Please contact
techsupport@origene.com
for a custom quote.

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Product Manuals |
FAQs |
SDS |
SKU | Description | Size | Price | |
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GA107907 | KLRK1 CRISPRa kit - CRISPR gene activation of human killer cell lectin like receptor K1 | 1 kit |
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KN208050 | KLRK1 - human gene knockout kit via CRISPR, HDR mediated | 1 kit |
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KN208050LP | KLRK1 - human gene knockout kit via CRISPR, HDR mediated | 1 kit |
$1,657.00
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KN208050RB | KLRK1 - human gene knockout kit via CRISPR, HDR mediated | 1 kit |
$1,657.00
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KN408050 | KLRK1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 kit |
$1,657.00
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.