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XIAP Human Gene Knockout Kit (CRISPR)

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SKU
KN207627LP
XIAP - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "XIAP or NM_001167"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol XIAP
Locus ID 331
Components

KN207627G1, XIAP gRNA vector 1 in pCas-Guide CRISPR vector

KN207627G2, XIAP gRNA vector 2 in pCas-Guide CRISPR vector

KN207627LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001167, NM_001204401, NR_037916
UniProt ID P98170
Synonyms API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1; MIHA; XLP2
Summary This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.provided by RefSeq, Feb 2011
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Documents
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Other Versions
SKU Description Size Price
GA100232 XIAP CRISPRa kit - CRISPR gene activation of human X-linked inhibitor of apoptosis 1 kit
$1,657.00
KN207627 XIAP - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN207627BN XIAP - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN207627RB XIAP - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN407627 XIAP - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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