YY1 Human Gene Knockout Kit (CRISPR)

CAT#: KN207198BN

YY1 - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Donor DNA: mBFP-Neo
• Symbol: YY1
• Locus ID: 7528
• Components:

  KN207198G1, YY1 gRNA vector 1 in pCas-Guide CRISPR vector

  KN207198G2, YY1 gRNA vector 2 in pCas-Guide CRISPR vector

  KN207198BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_003403
• UniProt ID: P25490
• Synonyms: DELTA; INO80S; NF-E1; UCRBP; YIN-YANG-1
• Summary: YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]