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CNOT1 Human Gene Knockout Kit (CRISPR)

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SKU
KN206903BN
CNOT1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "CNOT1 or AL833549"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol CNOT1
Locus ID 23019
Components

KN206903G1, CNOT1 gRNA vector 1 in pCas-Guide CRISPR vector

KN206903G2, CNOT1 gRNA vector 2 in pCas-Guide CRISPR vector

KN206903BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001265612, NM_016284, NM_206999, NR_049763
UniProt ID A5YKK6
Synonyms AD-005; CDC39; NOT1; NOT1H
Summary Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3' UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
GA107973 CNOT1 CRISPRa kit - CRISPR gene activation of human CCR4-NOT transcription complex subunit 1 1 kit
$1,657.00
KN206903 CNOT1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN206903LP CNOT1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN206903RB CNOT1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN406903 CNOT1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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