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BNP (NPPB) Human Gene Knockout Kit (CRISPR)

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SKU
KN206590BN
NPPB - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "BNP or NM_002521"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol BNP
Locus ID 4879
Components

KN206590G1, BNP gRNA vector 1 in pCas-Guide CRISPR vector

KN206590G2, BNP gRNA vector 2 in pCas-Guide CRISPR vector

KN206590BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_002521
UniProt ID P16860
Synonyms BNP
Summary This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. provided by RefSeq, Aug 2020
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Documents
Resources
Other Versions
SKU Description Size Price
GA103256 NPPB CRISPRa kit - CRISPR gene activation of human natriuretic peptide B 1 kit
$1,657.00
KN206590 NPPB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN206590LP NPPB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN206590RB NPPB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN406590 NPPB - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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