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Human BNP (NPPB) activation kit by CRISPRa

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SKU
GA103256
NPPB CRISPRa kit - CRISPR gene activation of human natriuretic peptide B
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA809046 NPPB mouse monoclonal antibody, clone OTI11G4 (formerly 11G4) 100 ul
$447.00
RC206590 NPPB (Myc-DDK-tagged)-Human natriuretic peptide B (NPPB)
10 ug
$225.00

Other products for "NPPB"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol NPPB
Locus ID 4879
Components

GA103256G1, BNP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103256G2, BNP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103256G3, BNP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_002521
UniProt ID P16860
Synonyms BNP
Summary This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. provided by RefSeq, Aug 2020
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Documents
Resources
Other Versions
SKU Description Size Price
KN206590 NPPB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN206590BN NPPB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN206590LP NPPB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN206590RB NPPB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN406590 NPPB - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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