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PSMA (FOLH1) Human Gene Knockout Kit (CRISPR)

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SKU
KN206548RB
FOLH1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "PSMA or NM_001014986"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol PSMA
Locus ID 2346
Components

KN206548G1, PSMA gRNA vector 1 in pCas-Guide CRISPR vector

KN206548G2, PSMA gRNA vector 2 in pCas-Guide CRISPR vector

KN206548RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001014986, NM_001193471, NM_001193472, NM_001193473, NM_004476, NM_001351236
UniProt ID Q04609
Synonyms FGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA
Summary This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. provided by RefSeq, Jul 2010
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Documents
Resources
Other Versions
SKU Description Size Price
GA101644 FOLH1 CRISPRa kit - CRISPR gene activation of human folate hydrolase 1 1 kit
$1,657.00
KN206548 FOLH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN206548BN FOLH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN206548LP FOLH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN406548 FOLH1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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