MTREX Human Gene Knockout Kit (CRISPR)

SKU
KN206080BN
SKIV2L2 - human gene knockout kit via CRISPR, HDR mediated
$1,657.00
4 Weeks*
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol MTREX
Locus ID 23517
Components

KN206080G1, MTREX gRNA vector 1 in pCas-Guide CRISPR vector

KN206080G2, MTREX gRNA vector 2 in pCas-Guide CRISPR vector

KN206080BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector

OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_015360
UniProt ID P42285
Synonyms Dob1; fSAP118; KIAA0052; Mtr4
Summary Component of exosome targeting complexes. Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (PubMed:17412707, PubMed:29107693). May be involved in pre-mRNA splicing.[UniProtKB/Swiss-Prot Function]
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More linear donor DNA can be ordered separately

Cat# KN206080BND
Description 10 ug linear donor DNA for KN206080BN kit
Price $515/€515
If you want to order 20ug, please order quantity of 2 for KN206080BND
If you want to order 50ug, please order quantity of 5 for KN206080BND

Other selection marker is available for donor DNA.
Please contact techsupport@origene.com for a custom quote.

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Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.