HMG1 (HMGB1) Human Gene Knockout Kit (CRISPR)

SKU KN205918BN

HMGB1 - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Vector: mBFP-Neo
• Target Symbol: HMG1
• Locus ID: 3146
• Components:

  KN205918G1, HMG1 gRNA vector 1 in pCas-Guide CRISPR vector

  KN205918G2, HMG1 gRNA vector 2 in pCas-Guide CRISPR vector

  KN205918BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001313892, NM_001313893, NM_002128, NM_001363661, NM_001370339, NM_001370340, NM_001370341
• UniProt ID: P09429
• Synonyms: HMG1; HMG3; SBP-1
• Summary: This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]
• Shipping: Ambient