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GRP78 (HSPA5) Human Gene Knockout Kit (CRISPR)

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SKU
KN205859BN
HSPA5 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "GRP78 or NM_005347"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol GRP78
Locus ID 3309
Components

KN205859G1, GRP78 gRNA vector 1 in pCas-Guide CRISPR vector

KN205859G2, GRP78 gRNA vector 2 in pCas-Guide CRISPR vector

KN205859BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_005347
UniProt ID P11021
Synonyms BIP; GRP78; HEL-S-89n; MIF2
Summary The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. provided by RefSeq, Jul 2020
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Documents
Resources
Other Versions
SKU Description Size Price
GA102261 HSPA5 CRISPRa kit - CRISPR gene activation of human heat shock protein family A (Hsp70) member 5 1 kit
$1,657.00
KN205859 HSPA5 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN205859LP HSPA5 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN205859RB HSPA5 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN405859 HSPA5 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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