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Endothelin B Receptor (EDNRB) Human Gene Knockout Kit (CRISPR)

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SKU
KN204899
EDNRB - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

RC204899 EDNRB (Myc-DDK-tagged)-Human endothelin receptor type B (EDNRB), transcript variant 1
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TT300007S A non-viral, non-electroporation, non-liposomal transfection kit using engineered mammalian proteins, tailored for high-efficiency delivery into a wide range of primary cells and difficult to transfect cell lines such as immune cells, stem cells, and neuronal cells.
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Other products for "Endothelin B Receptor or NM_000115"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
Vector GFP-puro
Target Symbol Endothelin B Receptor
Locus ID 1910
Components

KN204899G1, Endothelin B Receptor gRNA vector 1 in pCas-Guide CRISPR vector, Target Sequence: AAGTCTGTGCGGACGCGCCC

KN204899G2, Endothelin B Receptor gRNA vector 2 in pCas-Guide CRISPR vector, Target Sequence: CTGCGGCCTGTCGCGGATCT

KN204899D, donor DNA containing left and right homologous arms and GFP-puro functional cassette.

Homologous arm and GFP-puro sequences:

pUC vector backbone in gray; Left arm sequence in blue; GFP-puro in green; Right arm in violet

TCCGAATCTC CGGCGCACTC CTGGGCGCGC TGCGGGAGCT GTAGCTCAGC CAGCCAGGGA GTAGCGGCTT TCATCCGCCG GGAGGAGTCT TTCGAGTTCA ATCGCGGGGT ATAGAGGTTC CCCTGCGGGG CAAAATGCAG AGCTTGACAC AAGCCCTTGG CCTCTAGGTG CCTTAATTCC GCGGTTCCCA CGCACGCTTA ACTAAGACGT GTCTGTATTC CTCCCGTTAC GTGAAAGAGT TCGGAGCTTT GCCTGGGACC CCCATCATTC CCTCCCTGGC ACACCCCTTC CAGAACGCCC CGCCCCACTG CATATTATTT ACCCCTCCTG GCCACGCGGG GGAAGAAAAA CAGCTGAGAG GGCATCAGGA AGGAGTTTCG ACCCGCGCTG GCGAGTCATG AGCGCCAAGT TTCCCACTGG CGCGCAAACT TGAGTTACTT TTGAGCGTGG ATACTGGCGA AGAGGCTGCG GGCGGTATTA GCGTTTGCAG CGACTTGGCT CGGGCAGCTG ACCCAAGTGT CCTGTCTTCC TTCCTCTGCT TGTCTCTAGG CTCTGAAACT GCGGAGCGGC CACCGGACGC CTTCTGGAGC AGGTAGCAGC CAGAGATAAT GACGCCACCC ACTAAGACCT TATGGCCCAA GGGTTCCAAC GCCAGTCTGG CGCGGTCGTT GGCACCTGCG GAGGTGCCTA AAGGAGACAG GACGGCAGGA TCTCCGCCAC GCACCATCTC CCCTCCCCCG TGCCAAGGAC CCATCGAGAT CAAGGAGACT TTCAAATACA TCAACACGGT TGTGTCCTGC CTTGTGTTCG TGCTGGGGAT CATCGGGAAC TCCACACTTC TGAGAATTAT CTACAAGAAC AAGTGCATGC GAAACGGTCC CAATATCTTG ATCGCCAGCT TGGCTCTGGG AGACCTGCTG CACATCGTCA TTGACATCCC TATCAATGTC TACAAGGTAA AGGGCGCCTG CTGAAATCAT GGTGGGCTTG AGGAAGGGGG CCTGGTTGGA GACGGGGAGA TGAGAAAGCT TGTAGAGGGA GCTTCCCTTT AGCTCCCTCT TAAGGTTCTG CCCCTCCTAA AAGTCAGTAA TCTTTGGAAC CAAATTCCAT TTGGTTCTGT CCACTCATAA AAGTCAGTAA CCATTGGAAT AAAATTCCAT TCAGGTCTTC AGTAGACCTC TGCTAAGCTT AGGACAAGCG

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000115, NM_001122659, NM_001201397, NM_003991
UniProt ID P24530
Synonyms ABCDS; ET-B; ET-BR; ETB; ETBR; ETRB; HSCR; HSCR2; WS4A
Summary The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. provided by RefSeq, Oct 2016
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Documents
Resources
Other Versions
SKU Description Size Price
GA101331 EDNRB CRISPRa kit - CRISPR gene activation of human endothelin receptor type B 1 kit
$1,657.00
KN204899BN EDNRB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN204899LP EDNRB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN204899RB EDNRB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN404899 EDNRB - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

Cerebral vasoconstriction reactions and plasma levels of ETBR, ET-1, and eNOS in patients with chronic high altitude disease
Wu, Hao, Zhang et al
Mol Med Rep (2016) 14 (3), 2497-502 DOI: 10.3892/mmr.2016.5555
Cited by 8
AI Summary: OriGene products, specifically the Human EDNRB (ETBR) ELISA Kit (Cat# SEB693Hu) and Human NOS3 (eNOS) ELISA Kit (Cat# SEK183Hu), were used to quantitatively measure plasma levels of ETBR and eNOS in this study, contributing to the assessment of vascular biomarkers in patients with chronic high altitude disease.
FigureFigureFigure
Showing 1-1 of 1 papers.
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