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p15 INK4b (CDKN2B) Human Gene Knockout Kit (CRISPR)

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SKU
KN204895BN
CDKN2B - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "p15 INK4b or NM_004936"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol p15 INK4b
Locus ID 1030
Components

KN204895G1, p15 INK4b gRNA vector 1 in pCas-Guide CRISPR vector

KN204895G2, p15 INK4b gRNA vector 2 in pCas-Guide CRISPR vector

KN204895BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_004936, NM_078487
UniProt ID P42772
Synonyms CDK4I; INK4B; MTS2; P15; p15INK4b; TP15
Summary This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. provided by RefSeq, Jul 2008
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Other Versions
SKU Description Size Price
GA100742 CDKN2B CRISPRa kit - CRISPR gene activation of human cyclin dependent kinase inhibitor 2B 1 kit
$1,657.00
KN204895 CDKN2B - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN204895LP CDKN2B - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN204895RB CDKN2B - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN404895 CDKN2B - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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