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TAZ (WWTR1) Human Gene Knockout Kit (CRISPR)

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SKU
KN204082RB
WWTR1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "TAZ or NM_001168278"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol TAZ
Locus ID 25937
Components

KN204082G1, TAZ gRNA vector 1 in pCas-Guide CRISPR vector

KN204082G2, TAZ gRNA vector 2 in pCas-Guide CRISPR vector

KN204082RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001168278, NM_001168280, NM_015472, NM_001348362
UniProt ID Q9GZV5
Synonyms TAZ
Summary Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
GA108643 WWTR1 CRISPRa kit - CRISPR gene activation of human WW domain containing transcription regulator 1 1 kit
$1,657.00
KN204082 WWTR1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN204082BN WWTR1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN204082LP WWTR1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN404082 WWTR1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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