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Human TAZ (WWTR1) activation kit by CRISPRa

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SKU
GA108643
WWTR1 CRISPRa kit - CRISPR gene activation of human WW domain containing transcription regulator 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA503538 WWTR1 (TAZ) mouse monoclonal antibody, clone OTI1H9 (formerly 1H9) 100 ul
$447.00
RC230001 WWTR1 (Myc-DDK-tagged)-Human WW domain containing transcription regulator 1 (WWTR1), transcript variant 2
10 ug
$686.00

Other products for "WWTR1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol WWTR1
Locus ID 25937
Components

GA108643G1, TAZ gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA108643G2, TAZ gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA108643G3, TAZ gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001168278, NM_001168280, NM_015472, NM_001348362
UniProt ID Q9GZV5
Synonyms TAZ
Summary Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN204082 WWTR1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN204082BN WWTR1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN204082LP WWTR1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN204082RB WWTR1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN404082 WWTR1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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