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WASP (WAS) Human Gene Knockout Kit (CRISPR)

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SKU
KN203457LP
WAS - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "WASP or NM_000377"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol WASP
Locus ID 7454
Components

KN203457G1, WASP gRNA vector 1 in pCas-Guide CRISPR vector

KN203457G2, WASP gRNA vector 2 in pCas-Guide CRISPR vector

KN203457LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000377
UniProt ID P42768
Synonyms IMD2; SCNX; THC; THC1; WASP; WASPA
Summary The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
GA105136 WAS CRISPRa kit - CRISPR gene activation of human WASP actin nucleation promoting factor 1 kit
$1,657.00
KN203457 WAS - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN203457BN WAS - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN203457RB WAS - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN403457 WAS - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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