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Alpha B Crystallin (CRYAB) Human Gene Knockout Kit (CRISPR)

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SKU
KN202718LP
CRYAB - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Alpha B Crystallin or NM_001289807"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Alpha B Crystallin
Locus ID 1410
Components

KN202718G1, Alpha B Crystallin gRNA vector 1 in pCas-Guide CRISPR vector

KN202718G2, Alpha B Crystallin gRNA vector 2 in pCas-Guide CRISPR vector

KN202718LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001289807, NM_001289808, NM_001330379, NM_001885, NM_001368245, NM_001368246
UniProt ID P02511
Synonyms CMD1II; CRYA2; CTPP2; CTRCT16; HEL-S-101; HSPB5; MFM2
Summary Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jan 2019
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Documents
Resources
Other Versions
SKU Description Size Price
GA100992 CRYAB CRISPRa kit - CRISPR gene activation of human crystallin alpha B 1 kit
$1,657.00
KN202718 CRYAB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202718BN CRYAB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202718RB CRYAB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN402718 CRYAB - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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