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Human Alpha B Crystallin (CRYAB) activation kit by CRISPRa

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SKU
GA100992
CRYAB CRISPRa kit - CRISPR gene activation of human crystallin alpha B
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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Other products for "CRYAB"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CRYAB
Locus ID 1410
Components

GA100992G1, Alpha B Crystallin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA100992G2, Alpha B Crystallin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA100992G3, Alpha B Crystallin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001289807, NM_001289808, NM_001330379, NM_001885, NM_001368245, NM_001368246
UniProt ID P02511
Synonyms CMD1II; CRYA2; CTPP2; CTRCT16; HEL-S-101; HSPB5; MFM2
Summary Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jan 2019
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Documents
Resources
Other Versions
SKU Description Size Price
KN202718 CRYAB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202718BN CRYAB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202718LP CRYAB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202718RB CRYAB - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN402718 CRYAB - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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