DR4 (TNFRSF10A) Human Gene Knockout Kit (CRISPR)

SKU KN202152BN

TNFRSF10A - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Vector: mBFP-Neo
• Target Symbol: DR4
• Locus ID: 8797
• Components:

  KN202152G1, DR4 gRNA vector 1 in pCas-Guide CRISPR vector

  KN202152G2, DR4 gRNA vector 2 in pCas-Guide CRISPR vector

  KN202152BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_003844
• UniProt ID: O00220
• Synonyms: APO2; CD261; DR4; TRAILR-1; TRAILR1
• Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
• Shipping: Ambient