Human DR4 (TNFRSF10A) activation kit by CRISPRa

SKU GA105843

TNFRSF10A CRISPRa kit - CRISPR gene activation of human TNF receptor superfamily member 10a

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: TNFRSF10A
• Locus ID: 8797
• Components:

  GA105843G1, DR4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105843G2, DR4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105843G3, DR4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_003844
• UniProt ID: O00220
• Synonyms: APO2; CD261; DR4; TRAILR-1; TRAILR1
• Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]