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Granulin (GRN) Human Gene Knockout Kit (CRISPR)

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SKU
KN202139LP
GRN - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Granulin or NM_001012479"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Granulin
Locus ID 2896
Components

KN202139G1, Granulin gRNA vector 1 in pCas-Guide CRISPR vector

KN202139G2, Granulin gRNA vector 2 in pCas-Guide CRISPR vector

KN202139LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001012479, NM_002087
UniProt ID P28799
Synonyms acrogranin; GEP; GEP, GP88, PEPI, PGRN, PCDGF; GP88; granulin; granulin-epithelin; PC cell-derived growth factor; PCDGF; PEPI; PGRN; proepithelin; progranulin
Summary Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. provided by RefSeq, Jul 2008
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Documents
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Other Versions
SKU Description Size Price
GA101952 GRN CRISPRa kit - CRISPR gene activation of human granulin precursor 1 kit
$1,657.00
KN202139 GRN - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202139BN GRN - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202139RB GRN - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN402139 GRN - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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