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Human Granulin (GRN) activation kit by CRISPRa

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SKU
GA101952
GRN CRISPRa kit - CRISPR gene activation of human granulin precursor
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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Other products for "GRN"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol GRN
Locus ID 2896
Components

GA101952G1, Granulin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101952G2, Granulin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101952G3, Granulin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001012479, NM_002087
UniProt ID P28799
Synonyms acrogranin; GEP; GEP, GP88, PEPI, PGRN, PCDGF; GP88; granulin; granulin-epithelin; PC cell-derived growth factor; PCDGF; PEPI; PGRN; proepithelin; progranulin
Summary Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN202139 GRN - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202139BN GRN - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202139LP GRN - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202139RB GRN - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN402139 GRN - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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