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MGMT Human Gene Knockout Kit (CRISPR)

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SKU
KN201612LP
MGMT - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

RC229131 MGMT (Myc-DDK-tagged)-Human O-6-methylguanine-DNA methyltransferase (MGMT)
10 ug
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TT300007S A non-viral, non-electroporation, non-liposomal transfection kit using engineered mammalian proteins, tailored for high-efficiency delivery into a wide range of primary cells and difficult to transfect cell lines such as immune cells, stem cells, and neuronal cells.
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Other products for "MGMT or NM_002412.5"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol MGMT
Locus ID 4255
Components

KN201612G1, MGMT gRNA vector 1 in pCas-Guide CRISPR vector

KN201612G2, MGMT gRNA vector 2 in pCas-Guide CRISPR vector

KN201612LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_002412
UniProt ID P16455
Synonyms methylguanine-DNA methyltransferase; O-6-methylguanine-DNA methyltransferase; O6-methylguanine-DNA methyltransferase; OTTHUMP00000020741
Summary Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. provided by RefSeq, Sep 2015
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Other Versions
SKU Description Size Price
GA102900 MGMT CRISPRa kit - CRISPR gene activation of human O-6-methylguanine-DNA methyltransferase 1 kit
$1,657.00
KN201612 MGMT - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201612BN MGMT - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201612RB MGMT - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN401612 MGMT - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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