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MTH1 (NUDT1) Human Gene Knockout Kit (CRISPR)

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SKU
KN201148LP
NUDT1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "MTH1 or NM_002452"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol MTH1
Locus ID 4521
Components

KN201148G1, MTH1 gRNA vector 1 in pCas-Guide CRISPR vector

KN201148G2, MTH1 gRNA vector 2 in pCas-Guide CRISPR vector

KN201148LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_002452, NM_198948, NM_198949, NM_198950, NM_198952, NM_198953, NM_198954, NM_001367553, NM_001367554, NM_001367555, NR_160264
UniProt ID P36639
Synonyms MTH1
Summary Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. provided by RefSeq, Dec 2018
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Documents
Resources
Other Versions
SKU Description Size Price
GA103013 NUDT1 CRISPRa kit - CRISPR gene activation of human nudix hydrolase 1 1 kit
$1,657.00
KN201148 NUDT1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201148BN NUDT1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201148RB NUDT1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN401148 NUDT1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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