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Human MTH1 (NUDT1) activation kit by CRISPRa

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SKU
GA103013
NUDT1 CRISPRa kit - CRISPR gene activation of human nudix hydrolase 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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100 ul
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RC208551 NUDT1 (Myc-DDK-tagged)-Human nudix (nucleoside diphosphate linked moiety X)-type motif 1 (NUDT1), transcript variant 1
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Other products for "NUDT1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol NUDT1
Locus ID 4521
Components

GA103013G1, MTH1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103013G2, MTH1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103013G3, MTH1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_002452, NM_198948, NM_198949, NM_198950, NM_198952, NM_198953, NM_198954, NM_001367553, NM_001367554, NM_001367555, NR_160264
UniProt ID P36639
Synonyms MTH1
Summary Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. provided by RefSeq, Dec 2018
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Documents
Resources
Other Versions
SKU Description Size Price
KN201148 NUDT1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201148BN NUDT1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201148LP NUDT1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201148RB NUDT1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN401148 NUDT1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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