PTDSS1 Human Gene Knockout Kit (CRISPR)

SKU KN201012RB

PTDSS1 - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
• Vector: RFP-BSD
• Target Symbol: PTDSS1
• Locus ID: 9791
• Components:

  KN201012G1, PTDSS1 gRNA vector 1 in pCas-Guide CRISPR vector

  KN201012G2, PTDSS1 gRNA vector 2 in pCas-Guide CRISPR vector

  KN201012RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001290225, NM_014754
• UniProt ID: P48651
• Synonyms: LMHD; PSS1; PSSA
• Summary: The protein encoded by this gene catalyzes the formation of phosphatidylserine from either phosphatidylcholine or phosphatidylethanolamine. Phosphatidylserine localizes to the mitochondria-associated membrane of the endoplasmic reticulum, where it serves a structural role as well as a signaling role. Defects in this gene are a cause of Lenz-Majewski hyperostotic dwarfism. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
• Shipping: Ambient