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ERCC1 Human Gene Knockout Kit (CRISPR)

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SKU
KN200478RB
ERCC1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "ERCC1 or NM_001166049"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol ERCC1
Locus ID 2067
Components

KN200478G1, ERCC1 gRNA vector 1 in pCas-Guide CRISPR vector

KN200478G2, ERCC1 gRNA vector 2 in pCas-Guide CRISPR vector

KN200478RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001166049, NM_001983, NM_202001, NM_001369409, NM_001369414, NM_001369416, NM_001369419, NM_001369408, NM_001369410, NM_001369411, NM_001369412, NM_001369413, NM_001369415, NM_001369417, NM_001369418
UniProt ID P07992
Synonyms COFS4; RAD10; UV20
Summary The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. provided by RefSeq, Oct 2009
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Documents
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Other Versions
SKU Description Size Price
GA101444 ERCC1 CRISPRa kit - CRISPR gene activation of human ERCC excision repair 1, endonuclease non-catalytic subunit 1 kit
$1,657.00
KN200478 ERCC1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN200478BN ERCC1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN200478LP ERCC1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN400478 ERCC1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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