IRF5 Human Gene Knockout Kit (CRISPR)

CAT#: KN200458BN

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IRF5 - human gene knockout kit via CRISPR, HDR mediated

HDR-mediated knockout kit validation

USD 1,290.00

4 Weeks

    • 1 kit

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Product Data
Format 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
Donor DNA mBFP-Neo
Symbol IRF5
Locus ID 3663
Kit Components

KN200458G1, IRF5 gRNA vector 1 in pCas-Guide CRISPR vector

KN200458G2, IRF5 gRNA vector 2 in pCas-Guide CRISPR vector

KN200458BN-D, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector

Disclaimer The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001098627, NM_001098628, NM_001098629, NM_001098630, NM_001098631, NM_001242452, NM_002200, NM_032643, NM_001347928, NM_001364314
Synonyms SLEB10
Summary This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]


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Customer Reviews 
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
68 Mouse Clones