Nucleostemin (GNL3) Human Gene Knockout Kit (CRISPR)

SKU KN200066BN

GNL3 - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Vector: mBFP-Neo
• Target Symbol: Nucleostemin
• Locus ID: 26354
• Components:

  KN200066G1, Nucleostemin gRNA vector 1 in pCas-Guide CRISPR vector

  KN200066G2, Nucleostemin gRNA vector 2 in pCas-Guide CRISPR vector

  KN200066BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_014366, NM_206825, NM_206826
• UniProt ID: Q9BVP2
• Synonyms: C77032; E2IG3; NNP47; NS
• Summary: The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
• Shipping: Ambient