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LDL Receptor (LDLR) Human Gene Knockout Kit (CRISPR)

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SKU
KN200006RB
LDLR - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "LDL Receptor or NM_000527"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol LDL Receptor
Locus ID 3949
Components

KN200006G1, LDL Receptor gRNA vector 1 in pCas-Guide CRISPR vector

KN200006G2, LDL Receptor gRNA vector 2 in pCas-Guide CRISPR vector

KN200006RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000527, NM_001195798, NM_001195799, NM_001195800, NM_001195802, NM_001195803
UniProt ID P01130
Synonyms FH; FHC; LDLCQ2
Summary The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.provided by RefSeq, Sep 2010
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Documents
Resources
Other Versions
SKU Description Size Price
GA102675 LDLR CRISPRa kit - CRISPR gene activation of human low density lipoprotein receptor 1 kit
$1,657.00
KN200006 LDLR - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN200006BN LDLR - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN200006LP LDLR - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN400006 LDLR - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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