Mouse Dmrt2 activation kit by CRISPRa

SKU GA213819

Dmrt2 CRISPRa kit - CRISPR gene activation of mouse doublesex and mab-3 related transcription factor 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Dmrt2
• Locus ID: 226049
• Components:

  GA213819G1, Dmrt2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA213819G2, Dmrt2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA213819G3, Dmrt2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_145831
• UniProt ID: Q8BG36
• Synonyms: Terra
• Summary: Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome. Is not required for sex determination and/or differentiation in embryonic development. Also not involved in symmetric somite formation and hence does not regulate the laterality pathway that controls left-right asymmetric organ positioning.[UniProtKB/Swiss-Prot Function]