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Mouse Srebf1 activation kit by CRISPRa

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SKU
GA204103
Srebf1 CRISPRa kit - CRISPR gene activation of mouse sterol regulatory element binding transcription factor 1
  $1,657.00
4 Weeks*

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Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Srebf1
Locus ID 20787
Components

GA204103G1, Srebf1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA204103G2, Srebf1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA204103G3, Srebf1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_011480
UniProt ID Q9WTN3
Synonyms ADD1; bHLHd1; SREBP-1a; SREBP1; SREBP1c
Summary This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. Alternatively spliced transcript variants have been characterized for this gene. provided by RefSeq, Nov 2017
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Documents
Resources
Other Versions
SKU Description Size Price
KN516704 Srebf1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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