Mouse Pdgfra activation kit by CRISPRa

SKU GA203155

Pdgfra CRISPRa kit - CRISPR gene activation of mouse platelet derived growth factor receptor, alpha polypeptide

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Pdgfra
• Locus ID: 18595
• Components:

  GA203155G1, Pdgfra gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203155G2, Pdgfra gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203155G3, Pdgfra gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001083316, NM_011058, NR_144636
• UniProt ID: P26618
• Synonyms: AI115593; CD140a; Pdgfr-2
• Summary: This gene encodes a member of the receptor tyrosine kinase family of proteins. Binding of platelet-derived growth factor protein ligands to this receptor triggers receptor dimerization and autophosphorylation, resulting in the activation of several downstream signaling pathways. Signaling through the encoded receptor plays a role in gastrulation and the development of nearly all organ systems. Mice lacking a functional copy of this gene reportedly exhibit defects in lung, skeleton, testis and the central nervous system, and die soon after birth. Alternative splicing and intronic polyadenylation of gene transcripts have been implicated in muscle regeneration and fibrosis in adult mice. [provided by RefSeq, Jan 2017]