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Mouse Myd88 activation kit by CRISPRa

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SKU
GA202782
Myd88 CRISPRa kit - CRISPR gene activation of mouse myeloid differentiation primary response gene 88
  $1,657.00
4 Weeks*

Other products for "Myd88"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Myd88
Locus ID 17874
Components

GA202782G1, Myd88 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA202782G2, Myd88 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA202782G3, Myd88 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_010851
UniProt ID P22366
Summary Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:9697844). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9575168, PubMed:9697844). Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway (PubMed:9697844). Isoform 2 is defective in its ability to induce IRAK phosphorylation and NF-kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS) (PubMed:11909531). Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (PubMed:17018642). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (PubMed:17635956, PubMed:21998396). Mediates leukocyte recruitment at the inflammatory site (PubMed:18941239).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN310583 Myd88 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN310583BN Myd88 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN310583LP Myd88 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN310583RB Myd88 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN510583 Myd88 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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