Human D2HGDH activation kit by CRISPRa

SKU GA118924

D2HGDH CRISPRa kit - CRISPR gene activation of human D-2-hydroxyglutarate dehydrogenase

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: D2HGDH
• Locus ID: 728294
• Components:

  GA118924G1, D2HGDH gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA118924G2, D2HGDH gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA118924G3, D2HGDH gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001287249, NM_152783, NR_109778, NM_001352824
• UniProt ID: Q8N465
• Synonyms: D2HGD
• Summary: This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. [provided by RefSeq, Jul 2008]