Human NDUFS7 activation kit by CRISPRa

SKU GA117757

NDUFS7 CRISPRa kit - CRISPR gene activation of human NADH:ubiquinone oxidoreductase core subunit S7

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NDUFS7
• Locus ID: 374291
• Components:

  GA117757G1, NDUFS7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA117757G2, NDUFS7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA117757G3, NDUFS7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_024407, NM_001363602
• UniProt ID: O75251
• Synonyms: CI-20; CI-20KD; MY017; PSST
• Summary: This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. [provided by RefSeq, Jul 2008]